Neutrophil-borne heparin-binding protein (HBP) is a multifunctional protein involved in the progression of inflammation. HBP is stored in neutrophil granules and released upon stimulation of the cells in proximity to endothelial cells. HBP affects endothelial cells in multiple ways; however, the molecular and cellular mechanisms underlying the interaction of HBP with these cells are unknown. Af...

BACKGROUND Secular trend data on hypertension in children and adolescents are scarce and inconsistent. In the face of growing obesity, we sought to assess high blood pressure (HBP) secular trends in children and adolescents enrolled in national surveys and to determine whether the HBP trend reversed its course with the rise in obesity. METHODS AND RESULTS National survey data obtained from mu...

The hexosamine biosynthetic pathway (HBP) generates uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) for glycan synthesis and O-linked GlcNAc (O-GlcNAc) protein modifications. Despite the established role of the HBP in metabolism and multiple diseases, regulation of the HBP remains largely undefined. Here, we show that spliced X-box binding protein 1 (Xbp1s), the most conserved signal trans...

OBJECTIVE Determining characteristics regarding risk and high blood pressure (HBP) frequency in a group of 12 to 16 year-old students from the city of León, Mexico, according to two types of classification: the 7th Joint National Committee (JNC-7) and 4th report of the working group for diagnosis, evaluation and treatment of HBP in children and adolescents. METHODS This was an observational, ...

OBJECTIVES To identify barriers to achieving optimal management of high blood pressure (HBP) among hypertensive Korean-American elderly (KAE). METHODS This study used data on a subsample of 146 hypertensive KAE from a total of 205 KAE in Maryland who participated in a cardiovascular health assessment study. The study group consisted of 56 males and 90 females with a mean age of 69.8 +/- 6.6 y...

BACKGROUND Elevated plasma levels of heparin-binding protein (HBP) are associated with risk of organ dysfunction and mortality in sepsis, but little is known about causality and mechanisms of action of HBP. The objective of the present study was to test the hypothesis that HBP is a key mediator of the increased endothelial permeability observed in sepsis and to test potential treatments that in...

We investigated the electrophysiological effects of cardiac hypertrophy induced by renal hypertension in rats by comparing transmembrane action potentials (AP) recorded from the papillary muscles of hypertensive (HBP) and normal (SHAM) rats. No significant difference was found between HBP and SHAM AP with regard to resting membrane potential (RMP), action potential amplitude (AMP), overshoot (O...